Abstrato

A Case Report on Cardiovascular Enlargement and Linked Disorder in Down Patients With symptoms

Rajvika Paul

The availability of appropriate pharmaceutical and surgical treatments has significantly increased the survival rate of adrenal Cushing syndrome patients. Nevertheless, a significant risk factor for the survival of affected patients is the increased likelihood of a heart attack brought on by a cardiovascular event. Through glucocorticoid receptor activation, it has been demonstrated in experimental studies that hypercortisolemia causes cardiomyocyte hypertrophy. This includes the possibility of cross talk between several cardiomyocyte-related hypertrophy signals and the tissue-dependent regulation of 11-hydroxysteroid dehydrogenase type 1. In clinical cases, however, the factors are more complex because both geometric and functional impairments that lead to heart failure have been discovered. These impairments are crucially associated with a wide range of factors, such as hypertension. Also, very little is known about these changes in autonomous cortisol secretion, which have a high risk of causing heart attacks and overt Cushing syndrome. While functional disorders are contentious when considering the effects of treatment, partial improvement of structural alterations is anticipated. As a result, it is still unclear whether normalizing excessive cortisol reduces the risk of cardiac hypertrophy