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Apolipoprotein E key to inflammation and cholesterol efflux in atherosclerosis

Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Irina I. Nadelyaeva, Nikita A. Gutyrchik, Alexander N. Orekhov

Lipid metabolism is an often-underestimated aspect of health and its maintenance. However, lipids and their derivatives are involved in many key processes in the human body. ApoE is one of the important participants in lipid homeostasis. One of its remarkable properties is the ability to resist the development of atherosclerosis. Recently, data began to appear on various mechanisms that can mediate the anti- atherosclerotic effects of ApoE, including blocking the formation of foam cells and inhibiting increased hematopoiesis, among others. This suggests ample opportunities for the use of ApoE as an anti-atherosclerotic agent. In our review, we focused on the relationship of ApoE with inflammation and cholesterol in the context of atherogenesis. We also considered the possibilities of therapeutic application.