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Evaluation of the clinical efficacy of preoperative neoadjuvant chemotherapy combined with endocrine therapy for breast cancer
Shi'en Cui, Feihai Ling, Zhihua Huang & Shihui MaObjective: To analyze the clinical efficacy of preoperative neoadjuvant chemotherapy combined with endocrine therapy for breast cancer.
Methods: 50 cases of breast cancer patients without surgery treated in our hospital from December 2016 to June 2017 were randomly selected and divided into two groups, of which 25 patients in the control group were treated with neoadjuvant chemotherapy, and 25 patients in the observation group were treated with neoadjuvant chemotherapy plus endocrine therapy. The curative effect, CA153 and CA125 levels, quality of life and incidence of adverse reactions were compared between the two groups.
Results: After treatment, the total response rate in the observation group was 64.0% (16/25), which was significantly higher than that in the control group (32.0% (8/25)). The difference was statistically significant (P<0.05). The levels of CA153 and CA125 after treatment in the observation group were significantly lower than those of the control group (12.17 ± 1.8 vs. 21.12 ± 2.4, 13.96 ± 2.2 vs. 23.32 ± 2.6, respectively), the difference was statistically significant (P<0.05). The total effective rate of improvement in the quality of life of the observation group was significantly higher than that of the control group (88.0% (22/25) vs. 56.0% (14/25)), the difference was statistically significant (P<0.05). The incidence of clinical adverse reactions was lower in the observation group than in the control group, but the difference was not statistically significant (P>0.05).
Conclusion: The implementation of preoperative neoadjuvant chemotherapy combined with endocrine therapy in patients with breast cancer can significantly reduce the primary tumor of the patient without increasing the incidence of adverse reactions in patients. It can improve the quality of life of the patients and improve the rate of breast conserving surgery or resection of the patients.