Abstrato

Isoniazid Induced Psychosis: A Case Report

Rohit Bangwal, Jagdish Rawat, Yogesh Joshi

Psychosis is a known complication of isoniazid drug therapy, although infrequent. Isoniazid is the first line anti-tubercular agent for the treatment of tuberculosis. Tuberculosis is an important public health problem. First line therapy for tuberculosis includes isoniazid, rifampicin, ethambutol and pyrazinamide. A 27 years old male patient, 45 kg weighing, developed psychosis by first line antitubercular drugs therapy (ATT). As a clinical pharmacist (health care team member), patient history was done, he was not taking regular doses of tab pyridoxine 20 mg with anti-tubercular drugs therapy. Pulmonologist withdrawn the tablet isoniazid and tablet pyridoxine was added in the therapy. Patient recovered from psychosis withdrawn the tablet isoniazid. Psychosis in a patient on ATT can be one of the complications of tablet isoniazid. Pulmonologist & Clinical Pharmacist (health care team members) should be aware of this adverse effect of isoniazid and that it may present with a broad clinical picture. We need to monitor the vitals and systems at risk at regular intervals during the therapy. As a clinical pharmacist role, we prevent and minimize drug induced complications & ADRs. Proper patient counselling & patient’s education is important for the better management of patients.