Abstrato

Mitochondrion as one of the key targets in viral infection

Alexander V. Blagov, Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Alexander N. Orekhov

Viruses are able to affect cellular organelles to increase the productivity of reproduction, maintain tire viability of visions and evade the antiviral immune response. Understanding the mechanisms and knowledge of the proteins involved in the interaction of viruses with cellular structures allows for a better understanding of the pathogenesis of the virus and is the basis for the creation of antiviral drugs. Mitochondria is an important strategic target for viruses, capturing which viruses are able to change cell metabolism, regulate the cell cycle and inhibit the antiviral immune response. Using the example of SARS-CoV-2, a model of the viral effect on the mitochondria is shown: SARS-CoV-2 shifts metabolism to glycolysis and inhibits interferon production, which, as a result leads to increased inflammation, which is a characteristic feature of COVID-19. Based on the described model, we have discussed possible therapeutic strategies to combat COVID-19.