Abstrato

Preterm Labor

Abdul Hamid

Preterm birth is a leading cause of infant morbidity and mortality, affecting 5 to 18 percent of pregnancies. 70% of preterm births are the result of spontaneous preterm labor, a syndrome caused by multiple pathologic processes. Preterm labor has been difficult to prevent and treat for a long time. We review recent developments pertaining to intraamniotic infection, decidual senescence, and the breakdown of maternal-fetal tolerance as well as a summary of the current understanding of the disease mechanisms implicated in this condition. The outcome of progestogen treatment to forestall preterm birth in a subset of patients in danger is a reason for hopefulness. It would be a worthwhile investment to solve the mystery of preterm labor, which puts future generations’ health at risk.

Preterm birth is a leading cause of infant morbidity and mortality, affecting 5 to 18 percent of pregnancies. 70% of preterm births are the result of spontaneous preterm labor, a syndrome caused by multiple pathologic processes. Preterm labor has been difficult to prevent and treat for a long time. We review recent developments pertaining to intraamniotic infection, decidual senescence, and the breakdown of maternal-fetal tolerance as well as a summary of the current understanding of the disease mechanisms implicated in this condition. The outcome of progestogen treatment to forestall preterm birth in a subset of patients in danger is a reason for hopefulness. It would be a worthwhile investment to solve the mystery of preterm labor, which puts future generations’ health at risk.