Two-Dimensional Perfusion Angiography (2DPA) to predict outcome of peripheral angioplasty: A mini-review

Anouk S. Verschuur, Vincent van Weel

Predicting clinical outcome of endovascular procedures is subjective and difficult to quantify. Two-Dimensional Perfusion Angiography (2DPA) is a promising tool to quantitatively assess reperfusion during surgery. However, important issues regarding imaging protocols and Time Density Curve (TDC) analysis should be further investigated in a large prospective study before clinical implementation is possible. The aim of this mini-review was to highlight essential topics that must be addressed before clinical implementation of 2DPA is valid. The added value of 2DPA to predict clinical outcome should be assessed by investigating the relation between perioperative TDC parameter ratios (after/before angioplasty) and validated clinical scores and vascular tests during follow up. Standardization of imaging and study protocols is essential to provide reliable and reproducible measures and allow for correct assessment of the added value of 2DPA for predicting clinical outcome after peripheral arterial intervention.