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Recurrent life-threatening bleeding due to acquired clotting factor XIII inhibitor in a Chinese patient with systemic lupus erythematosus

Jacky Ka Hing Chan & Chi Keung Ching

A 52-year-old Chinese male with systemic lupus erythematosus presented with recurrent retroperitoneal haematoma and finally died of aggressive bleeding complications related to acquired clotting factor XIII inhibitor. We review different aspects of this rare but severe bleeding disorder with normal baseline coagulation studies.